Performance of a motor task learned ON levodopa deteriorates when subsequently practiced OFF
Identifieur interne : 000847 ( Main/Exploration ); précédent : 000846; suivant : 000848Performance of a motor task learned ON levodopa deteriorates when subsequently practiced OFF
Auteurs : E. D. Anderson ; F. B. Horak ; M. R. Lasarev ; J. G. NuttSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Female, Humans, Learning (drug effects), Learning (physiology), Levodopa (pharmacology), Levodopa (therapeutic use), Male, Middle Aged, Motor Skills (drug effects), Motor Skills (physiology), Movement (drug effects), Movement (physiology), Neuropsychological Tests, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Psychomotor Performance (drug effects), Psychomotor Performance (physiology).
- MESH :
- chemical , pharmacology : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug effects : Learning, Motor Skills, Movement, Psychomotor Performance.
- drug therapy : Parkinson Disease.
- physiology : Learning, Motor Skills, Movement, Psychomotor Performance.
- physiopathology : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
Studies in animals and in people with Parkinson's Disease (PD) demonstrate complex effects of dopamine on learning motor tasks; its effect on retention of motor learning has received little attention. Recent animal studies demonstrate that practicing a task in the OFF state, when initially learned in the ON state, leads to progressive deterioration in performance.
We measured the acquisition and retention of 3 different motor tasks in the presence and absence of levodopa. Twenty individuals with Hoehn and Yahr Stage 1.5-3 PD practiced the tasks for two, 4-day weeks, half practicing ON levodopa the first week and OFF the second week. The other half practiced OFF levodopa both weeks. The tasks were: 1. alternate tapping of two keys, 2. moving the body toward two targets on a posturography device and 3. mirror drawing of a star.
For the finger tapping and body movement tests, those who practiced ON the first week had a progressive decline in performance with practice during Week 2, while subjects OFF during Week 1 maintained or improved. In contrast, for the mirror task, subjects ON levodopa initially had much more difficulty completing the task compared to subjects who practiced OFF. Both groups improved with practice during the first week and had flat performance the second week.
These data suggest that performance of speed-accuracy tasks learned in the ON state may progressively worsen if practiced in the OFF state. In addition, performance, but not learning, of some tasks may be impeded by levodopa.
Url:
DOI: 10.1002/mds.25702
PubMed: 24132873
PubMed Central: 3943672
Affiliations:
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Le document en format XML
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Horak</name><affiliation><nlm:aff id="A3"> OHSU Department of Neurology</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> OHSU Department of Physiology & Pharmacology</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> OHSU Department of Biomedical Engineering</nlm:aff></affiliation></author><author><name sortKey="Lasarev, M R" sort="Lasarev, M R" uniqKey="Lasarev M" first="M. R." last="Lasarev">M. R. Lasarev</name><affiliation><nlm:aff id="A6"> Center for Research on Occupational and Environmental Toxicology</nlm:aff></affiliation></author><author><name sortKey="Nutt, J G" sort="Nutt, J G" uniqKey="Nutt J" first="J. G." last="Nutt">J. G. Nutt</name><affiliation><nlm:aff id="A1"> Parkinson Disease Research, Education and Clinical Center, Portland VA</nlm:aff><wicri:noCountry code="subfield">Portland VA</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2"> Oregon Health & Science University (OHSU)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24132873</idno><idno type="pmc">3943672</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943672</idno><idno type="RBID">PMC:3943672</idno><idno type="doi">10.1002/mds.25702</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000365</idno><idno type="wicri:Area/Pmc/Curation">000365</idno><idno type="wicri:Area/Pmc/Checkpoint">000091</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000713</idno><idno type="wicri:Area/PubMed/Curation">000713</idno><idno type="wicri:Area/PubMed/Checkpoint">000485</idno><idno type="wicri:Area/Ncbi/Merge">003D84</idno><idno type="wicri:Area/Ncbi/Curation">003D84</idno><idno type="wicri:Area/Ncbi/Checkpoint">003D84</idno><idno type="wicri:doubleKey">0885-3185:2013:Anderson E:performance:of:a</idno><idno type="wicri:Area/Main/Merge">000847</idno><idno type="wicri:Area/Main/Curation">000847</idno><idno type="wicri:Area/Main/Exploration">000847</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Performance of a motor task learned ON levodopa deteriorates when subsequently practiced OFF</title><author><name sortKey="Anderson, E D" sort="Anderson, E D" uniqKey="Anderson E" first="E. D." last="Anderson">E. D. Anderson</name><affiliation><nlm:aff id="A1"> Parkinson Disease Research, Education and Clinical Center, Portland VA</nlm:aff><wicri:noCountry code="subfield">Portland VA</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2"> Oregon Health & Science University (OHSU)</nlm:aff></affiliation></author><author><name sortKey="Horak, F B" sort="Horak, F B" uniqKey="Horak F" first="F. B." last="Horak">F. B. Horak</name><affiliation><nlm:aff id="A3"> OHSU Department of Neurology</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> OHSU Department of Physiology & Pharmacology</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> OHSU Department of Biomedical Engineering</nlm:aff></affiliation></author><author><name sortKey="Lasarev, M R" sort="Lasarev, M R" uniqKey="Lasarev M" first="M. R." last="Lasarev">M. R. Lasarev</name><affiliation><nlm:aff id="A6"> Center for Research on Occupational and Environmental Toxicology</nlm:aff></affiliation></author><author><name sortKey="Nutt, J G" sort="Nutt, J G" uniqKey="Nutt J" first="J. G." last="Nutt">J. G. Nutt</name><affiliation><nlm:aff id="A1"> Parkinson Disease Research, Education and Clinical Center, Portland VA</nlm:aff><wicri:noCountry code="subfield">Portland VA</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2"> Oregon Health & Science University (OHSU)</nlm:aff></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (pharmacology)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Female</term><term>Humans</term><term>Learning (drug effects)</term><term>Learning (physiology)</term><term>Levodopa (pharmacology)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Motor Skills (drug effects)</term><term>Motor Skills (physiology)</term><term>Movement (drug effects)</term><term>Movement (physiology)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (drug effects)</term><term>Psychomotor Performance (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Learning</term><term>Motor Skills</term><term>Movement</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Learning</term><term>Motor Skills</term><term>Movement</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Studies in animals and in people with Parkinson's Disease (PD) demonstrate complex effects of dopamine on learning motor tasks; its effect on retention of motor learning has received little attention. Recent animal studies demonstrate that practicing a task in the OFF state, when initially learned in the ON state, leads to progressive deterioration in performance.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We measured the acquisition and retention of 3 different motor tasks in the presence and absence of levodopa. Twenty individuals with Hoehn and Yahr Stage 1.5-3 PD practiced the tasks for two, 4-day weeks, half practicing ON levodopa the first week and OFF the second week. The other half practiced OFF levodopa both weeks. The tasks were: 1. alternate tapping of two keys, 2. moving the body toward two targets on a posturography device and 3. mirror drawing of a star.</p></sec><sec id="S3"><title>Results</title><p id="P3">For the finger tapping and body movement tests, those who practiced ON the first week had a progressive decline in performance with practice during Week 2, while subjects OFF during Week 1 maintained or improved. In contrast, for the mirror task, subjects ON levodopa initially had much more difficulty completing the task compared to subjects who practiced OFF. Both groups improved with practice during the first week and had flat performance the second week.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">These data suggest that performance of speed-accuracy tasks learned in the ON state may progressively worsen if practiced in the OFF state. In addition, performance, but not learning, of some tasks may be impeded by levodopa.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Anderson, E D" sort="Anderson, E D" uniqKey="Anderson E" first="E. D." last="Anderson">E. D. Anderson</name><name sortKey="Horak, F B" sort="Horak, F B" uniqKey="Horak F" first="F. B." last="Horak">F. B. Horak</name><name sortKey="Lasarev, M R" sort="Lasarev, M R" uniqKey="Lasarev M" first="M. R." last="Lasarev">M. R. Lasarev</name><name sortKey="Nutt, J G" sort="Nutt, J G" uniqKey="Nutt J" first="J. G." last="Nutt">J. G. Nutt</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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